Papers and Preprints from 2017-2020. Click here for a full list and citation data.

Worsley SF,. Macey M, Wilkinson B, Murrell JC and Hutchings MI (2020). 13CO2 DNA stable isotope probing reveals the winners and losers in the Arabidopsis thaliana root microbiome. Submitted.

Worlsey SF, Newitt JT, Rassbach J, Batey SFD, Holmes NA, Murrell JC, Wilkinson B* and Hutchings MI* (2020). Streptomyces endophytes promote the growth of Arabidopsis thaliana. Under review. Preprint at bioRxiv.

Qin Z, Devine R, Booth TJ, Farrar EHE, Grayson MN, Hutchings MI* and Wilkinson B* (2020). Transformation of the fasamycin to formicamycin polyketide skeleton involves a novel reductive ring contraction. Chem Sci, revised manuscript submitted.

Vikeli E, Widdick DA, Batey SF, Heine D, Holmes NA, Bibb MJ, Pierce N, Hutchings MI* and Wilkinson B* (2020). In situ activation and heterologous production of a cryptic lantibiotic from a plant-ant derived Saccharopolyspora species. App Env Microbiol 86:e01876-19. Abstract.

Hutchings MI, Truman A and Wilkinson B (2019). Antibiotics: past, present and future. Curr Op Microbiol. 51:72-80. Abstract

Qin Z#, Devine R#, Hutchings MI* and Wilkinson B* (2019). A role for ABM domain proteins in fidelity control during aromatic polyketide biosynthesis. Nature Comms 10:3611. Abstract

McLean T, Lo R, Tschowri N, Hoskisson PA, Al Bassam MM, Hutchings MI and Som N (2019). Sensing and responding to diverse extracellular signals: An updated analysis of the sensor kinases and response regulators of Streptomyces spp. Microbiology 165:929-52. Abstract

McLean T, Wilkinson B, Hutchings MI and Devine R (2019). Dissolution of the disparate: co-ordinate regulation in antibiotic biosynthesis. Antibiotics. 8:83. Abstract.

Newitt JT, Prudence SMM, Hutchings MI and Worsley SF (2019). Biocontrol of cereal crop diseases using streptomycetes. Pathogens. 8:78 Abstract.

Tran NT, Huang X, Hong H-J, Bush MJ, Chandra G, Pinto D, Bibb MJ, Hutchings MI, Mascher T and Buttner MJ (2019). Defining the regulon of genes controlled by σE, a key regulator of the cell envelope stress response in Streptomyces coelicolor. Mol. Microbiol. 112:461-81. Abstract

Volbeda A., Pellicer Martinez MT, Crack JC, Gigarel O, Munnoch JT, Hutchings MI, Darnault C, Le Brun NE, Fontecilla-Camps JC (2019). The Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu and His Residues. J Am Chem Soc 141:2367-75.

Leftwich P, Hutchings MI and Chapman T (2018). Diet, Microbes and Host Mate Choice. Bioessays. 40:1800053. Abstract.

Worsley SF, Innocent TM, Heine D, Murrell JC, Yu DW, Wilkinson B, Hutchings MI, Boomsma JJ and Holmes NA (2018). Symbiotic Partnerships and their Chemical Interactions in the Leafcutter Ants (Hymenoptera: Formicidae). Myrmecological News. 27:59-74. Abstract

Heine D#, Holmes NA#, Worsley SF, Alve dos Santos AC, Innocent TM, Scherlach K, Patrick E, Yu DW, Murrell JC, Boomsma JJ, Hertweck C, Hutchings MI* and Wilkinson B* (2018). Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen. Nature Comms. 9:2208.

Holmes NA, Devine R, Qin Z, Seipke RF, Wilkinson B, Hutchings MI (2018). Complete genome sequence of Streptomyces formicae KY5, the formicamycin producer. J Biotech. 265:116-8. Abstract

Leftwich PT, Clarke NVE, Hutchings MI and Chapman T (2017). Gut Microbiomes and reproductive isolation in Drosophila. Proc Natl Acad Sci USA. 114:12767-12772. Abstract. This paper led to a number of letters to PNAS and our responses were published by the journal:

  • Reply to Rosenberg et al: Diet, gut bacteria, and assortative mating in Drosophila melanogaster. Leftwich PT, Clarke NVE, Hutchings MI and Chapman T (2018). Proc Natl Acad Sci USA. 115: E2154-E2155 Full text
  • Reply to Obadia et al: Effect of methyl paraben on host-microbiota interactions in Drosophila melanogaster. Leftwich PT, Clarke NVE, Hutchings MI and Chapman T (2018). Proc Natl Acad Sci USA. 115:E4549-E4550. Full text

Som NF, Heine D, Holmes N, Knowles F, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B* and Hutchings MI* (2017). The MtrAB two component system controls antibiotic production in Streptomyces coelicolor A3(2). Microbiology. 163: 1415-1419. Abstract. bioRxiv preprint.

Som NF, Heine D, Holmes N, Munnoch JT, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B* and Hutchings MI* (2017). The conserved actinobacterial two-component system MtrAB coordinates chloramphenicol production with sporulation in Streptomyces venezuelae NRRL B-65442. Frontiers Microbiol. 8:1145. Abstract.

van der Meij A, Worsley SF, Hutchings MI and van Wezel GP (2017). Chemical ecology of antibiotic production by actinomycetes. FEMS Microbiol Rev. 41:392-416. Abstract.

Devine R, Hutchings MI* and Holmes NA* (2017). Future directions for the discovery of antibiotics from actinomycete bacteria. Emerging Topics in Life Sciences. 1:1-12. Abstract 

Volbeda A, Dodd EL, Darnault C, Crack JC, Renoux O, Hutchings MI, Le Brun NE and Fontecilla-Camps JC (2017). Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding. Nature Comms 8:15052. Abstract.

Qin Z, Munnoch, JT, Devine R, Holmes N, Seipke RF, Wilkinson B* and Hutchings MI* (2017). Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants. Chem. Sci. 8: 3218-3227 Abstract.